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Whether DAI exerts its DNA sensing role in particular cell types still remains elusive.
Soon afterwards, the DNA sensing role of cGAS was validated by genetic knockout models (Li et al., 2013b).
The TLRs have an immunological sensing role for bacterial, fungal, viral and parasitic organisms.
Previous studies in P. vivax has indicated that RH may have an initial sensing role preceding and possibly enabling the subsequent interaction of the EBP member with its corresponding receptor [23].
A base modification sensing role for F131 likely would not interfere with translocation by XPD.
Of these, NRT1.1 (At1g12110) has been implicated in stomatal aperture and drought stress [ 51] and its NO3- sensing role in root architecture was recently described [ 52].
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These observations suggest an under-appreciated overlap between NPHP gene functions in motile cilia with that of PCD genes in immotile cilia, which makes it difficult to segregate flow generating and flow sensing roles of protonephridial cilia.
These data are consistent with a potential acid-sensing role for TRPV4 reported previously (Suzuki et al., 2003).
In the top-down sense, roles can be engineered through scenario-driven interviews with members of an organization to address the expected needs of an organization [32, 33].
Conservation of His74 in the proton-sensitive ASIC3 that lacks a residue corresponding to Asp346 may suggest its possible pH-sensing role in proton-sensitive ASICs.
Therefore, it might be speculated that either (i) ASIC3 has a pH-sensing mechanism different from that of ASIC1 or (ii) both ASIC1 and ASIC3 have another common residue(s) that also plays a pH-sensing role.
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