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The integrated device is of a normally closed design having a break pressure of more than 68.9 kPa (517 mmHg), dimensions on the order of 1 mm × 2 mm × 2 mm, inert fluid contact surfaces, and senses flow.
Feeling my senses flow through a new kind of body changes me a little.
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Yet the molecules responsible for sensing flow (shear stress) within endothelial cells remain largely unknown.
It has been proposed that cilia may have mechanosensory functions sensing flow in the renal tubule and that the two proteins affected in ADPKD may jointly act as mechanosensors.
In that sense, flow cytometry multicentric clinical studies are essential.
One population of cilia was found to express dynein, is considered to be actively motile and to generate leftward flow, while the other population lacks dynein and is thought to sense flow (56).
One model suggests that the cilium functions as a mechanosensor to detect flow as a measure of tubule diameter and that cyst formation arises from a failure of the cilia to accurately sense flow (Nauli et al., 2003).
The endothelial cells lining the inside of the microvessels play a central role in this control system by sensing flow, metabolic, and other regulating substances to regulate arteriolar smooth-muscle-cell tone and capillary recruitment [ 4].
Roth et al. (1988) then demonstrated that primary cilia on cultured kidney epithelial cells could be bent by flow, and Wheatley (1995) suggested that if primary cilia in renal epithelia did not function properly in sensing flow, there would be pathophysiological consequences.
Most fish have the capability of sensing flows and nearby movements even in dark or murky conditions by using the lateral line organs.
Some evidence suggests that stationary rats can be trained to sense flowing air, but no one has studied them behaving naturally (not in the lab).
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CEO of Professional Science Editing for Scientists @ prosciediting.com