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PINK1 senses damaged mitochondria, and recruits and activates Parkin to ubiquitinate mitochondrial outer membrane proteins including mitofusins (Poole et al, 2010; Tanaka et al, 2010; Ziviani et al, 2010; Chen and Dorn, 2013; Sarraf et al, 2013) and Miro (Wang et al, 2011).
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The DNA damage checkpoint signalling cascade sense damaged DNA and coordinates cell cycle arrest, DNA repair, and/or apoptosis.
The pathways that sense damaged DNA and coordinate DNA repair, cell cycle arrest and/or apoptosis comprise the DNA damage checkpoint signalling cascade.
When the wing's nervous system senses damage, it sends a signal to microspheres of uncured material within the nanocrystal coating.
This is consistent with a recent report which suggests that the Rcs system senses damage to the peptidoglycan layer and contributes to low-level intrinsic beta-lactam antibiotic resistance, which is independent of colanic acid capsule synthesis [29].
For example, AIM2 could be an attractive candidate as it senses damage-associated molecular patterns, such as cytoplasmic and mitochondrial DNA, which are increased in NASH patients.
Because IscR senses damage to the Fe-S clusters of the cell, it is possible that iron limitation is generating some kind of stress in C. crescentus which is able to damage Fe-S clusters.
How does DSS1 sense proteins damaged by oxidative stress?
The source of the sensing damage of HPFRCC in tension significantly depends upon matrix cracking and fiber matrix debonding.
In a broad sense, damage to morale — which John Maynard Keynes called "animal spirits" — surely ranks as one of the most important reasons for the American economy's persistent weakness.
For example, if a monitor at a petrochemicals plant detects a power surge and automatically kills the utility feed, the Web server linking the equipment will sense damage to any drives (even if a backup generator has taken over).
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