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In contrast, ectopic expression of Wg alone induces Senseless expression in Wg-expressing and non-expressing cells where there is a lack of Notch activity (Figure 3D').
Using multigenerational selection experiments, we find that for the Drosophila proneural network, the effect of genomic diversity is dampened by miR-9a-mediated regulation of senseless expression.
Conversely, knockdown of Mad with RNAi (see below) caused decreased Senseless expression within clones (Figure 2H and 2I), which were accompanied in the adult wing by losses of the anterior wing margin within clones (Figure 2U).
Occasionally, we detected that f00391 was able to induce the Senseless expression defect even in wild-type eye discs (data not shown).
ELAV and Senseless expression patterns demonstrate that the hyperactivation of Psc leads to the same differentiation defects observed in the rbf1 120a;f00391 eye discs.
Although GMR-Gal4;failed failed to recapitulate the defect observed with ELAV staining, the same Senseless expression defect could be observed when Psc was overexpressed with GMR-Gal4.
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Following a particularly vile anti-semitic speech by a prominent member of the Nation, Chavis, then leader of America's oldest and most conservative civil rights organisation, the NAACP, said, "Our struggle for racial justice must never be diverted or derailed by the senseless expressions of anti-semitism and other hatred".
Note that the in silico figures (and movies) show Senseless protein expression, although this species was not considered in our modeling approach.
Wg induces senseless (sens) expression at a short range, whereas it activates distalless (dll) at a long range.
Although Senseless was expressed at the morphogenetic furrow, its expression was lost in the posterior region of the eye disc.
The hostage-taking is as complex as it is seemingly senseless, the full expression of a lawless world of pirates, smugglers and warlords, where kidnapping for ransom is a business and religious wars are fought by throwing bombs into markets and churches.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com