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Therefore, the continuous irrigation of normal epidermis with small amounts of circulating ammonia may play a positive role not only in the sense of activation of GS, but also in preservation of exchange between the skin and external world.
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In addition to the intracellular phosphate sensing, it has been hypothesized that Pho85 might also be influenced by a sensor for extracellular phosphate, similar to glucose sensing for activation of the cAMP-PKA pathway, in which also sensing systems for intracellular and extracellular glucose are involved.
Unstimulated phosphorylation of Akt might be a hallmark of sensing activation of other upstream molecules.
In this sense, activation activity was demonstrated as dependent on the CTR of ATHB12 in yeast [ 34].
These data can be compared with the capacity of central fructose to sense via activation of hypothalamic AMPK/malonyl-CoA signaling pathways [22].
Two such examples of this type of cellular sensing are activation of a well-described transcription factor known as HIF-1α (hypoxia-inducible factor), and another is the cellular thermostat called HSF (heat shock factor).
In the local sensing slot, all the SUs sense the activation of the PU in L subchannels and obtain the local sensing information.
For example, in the yeast S. cerevisiae, Burrill and co-workers [ 40] engineered a positive-feedback device to sense the activation of DNA damage response and trigger a persistent output from the circuit that functioned as memory device.
The latter specifies regulation biases and can take two values: b i =+1/2 if gene i is positively biased, in the sense that an equal number of activation and inhibition inputs will produce activation, and the reverse being the case if b i =−1/2.
Importantly, recent cell culture studies revealed a critical role of PIK3C3 in nutrient sensing and activation of mTOR complex 1 pathway.
Several studies have demonstrated that a strong sense of SP is associated with activation in a distributed brain network that specifically includes fronto-parietal regions [ 6- 10].
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