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The SEN calculation does not depend on perfect accuracy of the consensus structure and tolerates minor changes to the number of base pairs present.
Despite this potential drawback in the SEN calculation, by combining an alignment based reference structure and relaxing the distance measure to consider only core structure, SEN calculated neutrality better distinguishes structured RNAs from decoy sequences than existing approaches.
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However, the calculation for each sample structure is identical so SEN calculations have been implemented to run in parallel, which can significantly reduce the run time.
Writer met the sen.
Turkish: Ne dedin sen?
First, as a reference structure for neutrality calculation, SEN utilizes a consensus structure determined from an alignment of putative homologous sequences rather than an MFE structure, increasing the likelihood of utilizing a biologically relevant reference.
Sen gittin.
For example, Sen Elizabeth Warren challenged federal regulators including David Cohen, the undersecretary for terrorism and financial intelligence at the Department of the Treasury, in a Senate hearing in March 2013 about the calculation.
UPDATE from @sabrinasiddiqui: Sen.
Under the headline "Sen.
Sen did not.
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