Sentence examples for seminal trial from inspiring English sources

Glycemic control in that seminal trial was, however, relatively unsuccessful.

Answering these questions is continuing in the tradition of Spitzer and Sackett in their seminal trial of Nurse Practitioners in Canada in 1971 2 [ 5].

In that seminal trial, after the initial 7 years of treatment average A1C was >7.5% with a progressive and steady increase after initial improvement in glycemic control.

However, since the seminal trial by Langer et al comparing glibenclamide (glyburide) with insulin, 2 oral agents have been increasingly viewed as potential alternatives.

Tom Babor was a key figure in the major WHO brief interventions international collaborative project that developed through the 1980s and produced the AUDIT 45, and subsequently involved a seminal trial in 10 diverse countries 44, 46, 47.

Furthermore, in a post hoc analysis, a seminal trial found effluent rates exceeding 45 ml/kg/hour was associated with a survival benefit for a small subgroup of patients with septic AKI [ 16].

Since the early seminal trials, it has been recognized that the doses of eptifibatide previously used achieved only 30%to50%0% of maximal platelet GP IIb/IIIa integrin inhibition.

Based on two large seminal trials with an important septic subpopulation [89, 90], a CRRT dose of 20 25 ml/kg/h is currently issued by the KDIGO guidelines [45].

A better explanation may be that participation in trials as such, and not necessarily seminal trials, influences prescribing.

Three seminal trials have provided long-term (ie, 1-year) data on the efficacy of anti-TNFs when inducing remission or response in patients with moderately to severely active ulcerative colitis.

In their recent paper, Walley and colleagues speculated that a major reason why Norway has the highest use of statins in the region is "the involvement of Norwegian doctors in seminal trials" [ 13].