In his credit roll to his colleagues, Kubek cited one of baseball's seminal sequences: Coyle's direction of Carlton Fisk's game-winning, body-English home run to win Game 6 of the 1975 World Series.
The seminal Sequenced Treatment Alternative To Relieve Depression (STAR*D) study found that only 30% of individuals with MDD will remit with one full trial of antidepressant medication, and the remission rates for successive trials are even lower [ 3, 8].
Cinema has always been "about" visual movement, starting with 1902's The Great Train Robbery, with its seminal third sequence - shot from the top of a moving train.
Target sequences were selected in the coding region of each gene and were designed to broadly conform to the seminal studies of sequence features for siRNA oligomer efficacy [ 13- 15].
A recently published database of CAZyme domains, dbCAN [ 33, 34], can be employed to identify the frequency and diversity of CAZyme domains in plant genomes available on Phytozome [ 35]. dbCAN utilizes Hidden Markov Models (HMMs), based on the seminal CAZyme family sequence data available [ 13], to accurately and reproducibly identify CAZyme domains [ 33].
The chapter shows how these general principles are embodied in the seminal work on sequencing activities Newell and Simon's General Problem Solver (GPS) and discusses the way the Stanford Research Institute Problem Solver (STRIPS) extended the ideas of the GPS to activities of a robot such as pushing boxes between rooms.
In a seminal study on antibody sequences (Wu and Kabat, 1970), such large variability was exploited to correctly define these HV sequence stretches as the complementarity determining regions (CDRs) in antibody recognition.
The ability to alter an organism's genotype was made possible by seminal advancements in DNA sequencing, the understanding of cellular physiology, and the discovery and development of agents capable of mediating DNA transfer.
"Our overall plan is to allow the trial to proceed in cautious fashion while monitoring the potentially adverse finding of vector sequence in the seminal fluid and at the end of the study to bring it back to public discussion," Dr. Noguchi said.
