Using the Partin nomograms, Mr Smith has a risk of capsular penetration of about 28%, seminal vesicle involvement of 33% and lymph node involvement of 36%.
In intermediate-risk PCa patients, according to Partin's table [ 20], the probabilities for pT3, extracapsular extension (ECE), seminal vesicle involvement (SVI) and lymph node (LN) involvement are predicted to be 58 to 82%, 40 to 57%, 11 to 23% and 6 to 29%, respectively.
* P < 0.05 Likewise, the TGFBI methylation status of prostate cancer specimens was correlated with pathological features of the patients' prostatectomy specimens including those of locoregional invasiveness (i.e., extracapsular extension of tumor, seminal vesicle involvement by tumor, margin positivity with tumor, and/or regional lymph node tumor involvement) (Table 4).
To study the influence, in terms of prognosis, of the finding of seminal vesicle involvement in patients with prostate adenocarcinoma treated with radical prostatectomy.
The 08-032 tumor was scored Gleason 4+4, margin positive with seminal vesicle involvement.
*Variables removed from the model (P > 0.05): Gleason category, stage (pT) category, seminal vesicle involvement.
Seminal vesicle involvement or margin status was also previously associated with poorer outcome.
Patients were stratified into low- or moderate-risk groups for seminal vesicle involvement (Roach III, 1993).
Stratification of patients was according to calculated risks of seminal vesicle involvement (Roach III, 1993).
Tumour stage, Gleason sum (categorised <7; 7; >7), extraprostatic extension, seminal vesicle involvement and surgical margin showed a strong association with outcome (log rank; P<0.002).
