We recently reported that colon tumor cells stimulate macrophages to release IL-1β, which in turn inactivates GSK3β and enhances Wnt signaling in colon cancer cells, generating a self-amplifying loop that promotes the growth of tumor cells.
Local growth-promoting effectors at the growth cone, such as the self-amplifying autocrine promoter BDNF (Cheng et al., 2011) or netrin-1 (Argaw et al., 2011), may locally surmount this weak negative tone.
Furthermore, it is a self-amplifying problem, i.e., an increase in temperature causes more combustion reactions that would further increase the temperature.
The SAM® vaccine platform, now in pre-clinical development, is based on a synthetic, self-amplifying mRNA, delivered by a synthetic lipid nanoparticle (LNP).
This platform, now in preclinical development, is based on a synthetic, self-amplifying mRNA, delivered by a synthetic lipid nanoparticle (LNP).
The growth of microbial populations catalyzing biochemical reactions leads to positive feedback loops and self-amplifying process dynamics at ecosystem scales.
Self-amplifying replicon RNA (RepRNA) are large molecules 12-144 kb); their self-replication amplifies mRNA template numbers, affording several rounds of antigen production, effectively increasing vaccine antigen payloads.
Geall, A. J., Verma, A. & Otten, G. R. Nonviral delivery of self-amplifying RNA vaccines.
Therefore, PRV can be used as a self-amplifying tracer of neuronal circuits.
Steinhauer, J. Observation of self-amplifying Hawking radiation in an analogue black-hole laser.
We have developed a novel technology, the Self-Amplifying mRNA (SAM) platform, which is based on the synthesis of self-amplifying mRNA formulated and delivered as a vaccine.
