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Defects in self tolerance can lead to CD8+ immune responses that contribute to autoimmune pathologies [10].
This process allows T-cells to develop self tolerance (in the negative selection) while eliminating useless cells (positive selection).
Why these autoantibodies, which escape the normal mechanisms ensuring self tolerance, are made is still not fully understood.
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These cells dampen immune responses, which is important in maintenance of (self-) tolerance and homeostasis.
The immune system maintains self-tolerance through the interplay of several mechanisms.
This population of cells is critical for maintaining self-tolerance throughout the life of the organism.
T regulatory cells (Tregs) play a central role in maintaining self-tolerance and controlling autoimmune responses.
Tregs are ascribed immuno-suppressive functions as they induce self-tolerance and suppress allergy and asthma [27].
Tricky to do at first, self-tolerance is one of the greatest rewards you can give to yourself.
Rejection -- especially harsh or cruel rejection -- is a manifestation of self-insufficiencies and a lack of self-tolerance.
We examined this effect of self-tolerance on immunogenecity using our cross-reactivity model.
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