Exact(5)
The SALL4 self repression assay was performed using each of the promoter constructs.
At the same time self repression is limited in the presence of the inducer.
When Dach1 was perturbed using a morpholino specific to the start of translation, we saw by in situ hybridization an increased expression of dach1 (indicating self repression).
Thus we see that negative self repression is not a single mechanism for homeostasis but is a mechanism that might be performing quite different functions depending upon the strength of the repressor.
In this paper we address these questions by modeling the dynamical and stochastic behaviour of the iMSL circuit and comparing its properties to those of alternative regulatory strategies such as constitutive expression and transcriptional self repression.
Similar(55)
In this study, we have shown that consistent with its self-repression function, SALL4 represses the activities of the promoters of SALL1 and SALL3.
We explore a gene network motif in our experimental synthetic biology studies of two genes that mutually repress and activate each other with self-activation and self-repression.
We wonder at their self-repression.
Indeed, he links lovers and spies in their shared deceits and makes a connection, too, between English self-repression and efficacy at spying.
The purpose of Hailsham is to prepare them for their future - to help instal the powerful mechanisms of self-repression and denial that will keep them steady and dependable from one donation to the next.
But for Toibin, he stands as the negative example -- a figure who, because of his self-repression, not only didn't have a "gay life," but had no life at all.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com