Paul is a natural democrat, with easy manners and an intuitive appreciation for both hard work and honest pleasure, while Clément is punctilious and intolerant, perverted by his own self-repressing will and his unacknowledged guilt.
As pointed out in [ 18], the self-repressing and the self-activating genes can have overall similar distributions.
Finally for Network IV in the absence of Tc, Tet-OFF production is on and self-activating and TetR production is also on, but self-repressing.
Since the self-repressing network has a higher synthesis rate in unbound state (s1 = 50 > s0 = 10), it will produce more free proteins.
With Tc present, Tet-ON can bind on TetO, downstream of Ptet and self-repress while transcription of the reporter gene is on and activated by Tet-ON.
His complacent or muted unreliable narrators, like the painter Ono, in "An Artist of the Floating World," or the butler Stevens, in "The Remains of the Day," tell stories that mildly and self-servingly repress secrets, shameful compromises, and the wounds of the past.
In some cases, BRCA1 transcription is reduced sufficiently for methylation of the promoter to occur, creating a self-sustaining repressed state.
In this study, we have shown that consistent with its self-repression function, SALL4 represses the activities of the promoters of SALL1 and SALL3.
Bmi1 promotes neural stem self-renewal by repressing the p16 and p19 senescence pathways (Lessard and Sauvageau, 2003), but other studies have shown BMI1 controls neural stem self-renewal through p21-Rb pathway (Christopher A. Fasano et al., 2007).
These miRNAs may support differentiation by stably repressing self-renewal regulators and/or differentiation inhibitors.
Upon DNA damage, p53, like the differentiation cues during development, activates differentiation-associated genes while repressing self-renewal genes in ES cells [ 59].
