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The consequences of this diversification in the context of non self recognition in natural isolates will be discussed.
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Self- and non-self recognition in neurons is mediated by a family of proteins called clustered protocadherins.
It appears that self/non-self recognition in ascidians such as C. intestinalis is mechanistically similar to self-incompatibility systems in flowering plants.
HSP responses in human autoimmunity are exceptionally complex [10], [33] and are likely the result of a dynamic balance between self and non-self recognition in the context of apparently contradictory proinflammatory and tolerogenic signals [14], [34].
Several key molecules are involved in self/non-self recognition in the innate immune system.
CRT in hemocyte membranes participates in the non-self recognition in early-stage of the encapsulation.
We have previously identified the genes involved in self/non-self recognition in the colonial ascidian Botryllus schlosseri, and we can now begin to investigate their evolution.
Aside from a small number of cell-cell recognition genes, however, little is known about the genetic basis of self/non-self recognition in this species.
Hence, the means by which individuals recognize others, conspecific or otherwise, need to be uncovered (see refs. 62– 65 for a discussion of this topic of self/non-self recognition in relation to plant roots).
But the kinds of decisions that octopus arms can make on their own, such as those involved in self recognition and in complex camouflage, appear to be more complex than simple pain avoidance.
Interestingly, the gene was transiently upregulated during initial contact of self stolons, but dissipated rapidly following self recognition, while in non-self contacts high expression levels were maintained.
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