Self-proliferation and differentiation into distinct cell types have been made stem cell as a promising target for regenerative medicine.
Over-expressed Dpysl3 may promote TCs self-proliferation and cell-cell network forming.
It is possible that up-regulated Dpysl3 is indispensable for TCs self-proliferation and cell-cell network forming.
LIF, a member of the inflammatory IL-6 cytokine family [ 56], induced proliferation of premalignant epithelial cells [ 57] and stimulates self-proliferation of embryonic stem cells [ 58].
Type A spermatogonia divide to produce further type A spermatogonia (self-proliferation) and intermediate spermatogonia, which in turn differentiate into type B spermatogonia.
It is plausible that OPCs may lack glutamatergic synapses immediately after injury in order to promote self-proliferation, and synaptic inputs would only develop during the migration and maturation stages in preparation for further remyelination.
Cornea had upregulated gene expression related to cell cycling, self renewal, proliferation, cell differentiation growth factors, cytokines and SC signalling genes in the WNT, Notch, TGF-Beta pathways.
Therefore, understanding the influence of cytokines upon regulation of NSC self-renewal, proliferation and differentiation is crucial when designing therapies for CNS repair.
Self-renewal, proliferation and differentiation of HSCs are regulated through intrinsic signals from the BM niche in which the MSCs are a regulatory component [18], [19].
Hematopoietic stem cell (HSC) niche is a specific site in the marrow cavity where HSCs reside and undergo self-renewal, proliferation and differentiation[4].
CSCs share many characteristics with tissue stem cells, such as self-renewal, proliferation, chemoresistance, and are primarily responsible for sustaining the growth of tumors [27], [28].
