The combination of the multitopic contact sites of hydrogen bonds coupled with two bulky aromatic cores promoted the molecule to self-link into a solid-state supramolecular architecture, which was almost insoluble in water and common organic solvents.
This behavior concerns however only 28% of the users, and the self-links represent only 4% of the total number of links.
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Note that the communication network has self-links since it is possible for a user to write messages on his/her own shoutbox.
The weak intermolecular forces in recognition system direct the molecules toward self-linking in supramolecular engineering in the chemistry of life and material science.
For instance, networks can (1) have different types of nodes and/or links; (2) contain nodes and links with a variety of properties associated with them (e.g., weights); (3) have links that can be directed; (4) contain multi-links, self-links, and hyperlinks; and (5) contain nodes of two distinct types, with links running only between unlike types (called bipartite).
A slightly higher number of self-links in the yeast coAP/MS dataset compared to the combined yeast Y2H dataset argues for the former explanation.
The number of self-links, i.e. functional links on the diagonal of the matrix, can be assumed to give an indication of the functional organization in a dataset or a species.
We noticed that the number of self-links is larger in eukaryotes than in prokaryotes: T. pallidum (4 links, 1,039 genes), C. jejuni (6 links, 1,654 genes), E. coli (7 links [the average between [5] and [19]], 4,289 genes), yeast (16 links [Y2H], 20 links [Gavin], 6,200 genes).
The self-link for each gene is also considered but it is not counted toward the number of incoming links.
The possibility of protein homo-oligomerization can be explicitly taken into account by introducing 2 types of nodes corresponding respectively to i) self-interacting proteins with self-link loops and ii) non-self-interacting proteins without self-link loops, see Fig. S2 and Supporting Information.
