Sentence examples for self ligands from inspiring English sources

Non-self ligands usually promote inflammation and immunity, whereas self ligands are frequently involved in communication and tolerance.

The strength with which a T cell reacts to self ligands and the environmental context in which this reaction occurs influence almost every aspect of T cell biology, from development to differentiation to effector function.

Thus, the NKT cell TCR molds the β-linked self ligands to resemble the conformation of foreign α-linked ligands, which shows that induced-fit molecular mimicry can underpin the self-reactivity of NKT cell TCRs to β-linked antigens.

A potential role for TLR responses to self ligands in autoimmunity is emerging.

Chicz et al. (1993) suggest that the self peptides have a physiological role in modulating the immune response [10]: Since overstimulation by antigen can induce peripheral tolerance, the self ligands may serve not only to prevent antigenic peptides with short binding half-lives from binding, but also prevent over-presentation of foreign antigen in vivo.

In addition, TLR7- and TLR9-containing compartments may have differing abilities to access internalized ligands, influencing responses to microbial or self ligands.

Surprisingly, we find that this TCR utilizes a different strategy to engage the foreign pMHC in comparison to the manner in which it recognizes a self ligand H-2K(b -dEV8.

Surprisingly, we find that this TCR utilizes a different strategy to engage the foreign pMHC in comparison to the manner in which it recognizes a self ligand H-2Kb-dEV8.

Finally, the RNA-dependent helicase-derived peptide DDX17146 154 (p68) represents a well-defined self ligand with high affinity to HLA-A*0201 HLA-A*0201

Phagocytes such as macrophages contain a variety of pattern-recognition receptors (PRRs), which specifically recognize foreign organisms and modified self ligand.

Understanding how the variety of self and non-self ligands triggers differential CLR signalling and function presents a fascinating biological challenge.