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The screening cohort, characterized in the upper zone of Fig. 1, is expected to include at least 150,000 individuals coming from high-risk areas for CCA, including the self-enrolment of persons who feel that they are in danger of developing CCA.
Another possible limitation of this study is the self-initiated enrolment, which might produce potential bias because those people who volunteer may already be positively predisposed to SM [ 11, 50].
Three were enrolled full-time and six part-time; all had family and/or career commitments; and there was a mix of funded and self-funded enrolments.
The present analysis was based on observational data, where individuals self-selected insurance enrolment, which could have biased the results (27).
Bivariate probit regressions to take into account self selection into NHIS enrolment.
Participants in the self-testing arm receive four oral-fluid self-test kits at enrolment, with additional kits provided on request.
All participants completed a self-administered questionnaire on enrolment.
In brief, 41 836 women aged 55 69 years completed a self-administered survey at enrolment in 1986.
PA level and possible confounding factors were obtained through a self-administered questionnaire at enrolment.
In addition, patients who had not completed any part of the self-administered questionnaire at enrolment were also excluded.
Recruitment procedures from each of the three cohorts are similar, with the primary modes of enrolment being self-referral, street outreach, and word of mouth.
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