An essential prerequisite for the pathogenesis of autoimmune diseases is indeed the breakage of immunological tolerance, leading to the immune system mounting an effective and specific immune response against self determinants [10, 11].
Only one of these bacterial species (Vibrio splendidus 12B01) contained both, the "self" determinants of the tailed phage and the putative PM2-like prophage (see Additional file 1).
We show here that the previously proposed most conserved viral "self" determinants, the major coat protein and the packaging ATPase, were the only proteins that could be recognized in all detected corticoviral elements.
We show here that the previously proposed most conserved viral "self" determinants, the major coat protein and the packaging ATPase, were the only proteins that could be found in all detected corticoviral elements.
The core viral "self" determinants, genes II (protein P2) and IX (protein P9), are separated by the late promoter region and a short gene VII coding for structural protein P7.
In at least one case, a NITR specifically engages a non-self determinant (Cannon et al., unpublished observations), suggesting the possibility that they may be involved in cytotoxic interactions.
Autoimmune diseases such as multiple sclerosis (MS) are characterized by the loss of tolerance to self-determinants, activation of autoreactive lymphocytes and subsequent damage to single or multiple organs.
Formulas (21) and (22) reveal that the cyclic autocorrelation and spectra of a modulated signal are each self-determinant characteristics under an LPTV transformation.
What are the self-determinants of vote (environmental concerns, toll road efficiency, socio-economics factors)?
But, if I internalize my positive emotions as a reaction to my husband's praising, then I lose my ability to be self-determinant.
