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Traditionally drugs have been designed with the aim of targeting a single biological entity, usually a protein (the so-called "on-target"), with high selectivity to avoid any unwanted effects arising from mis-targeting other biological targets ("off-targets").
Methanol conversion must be carried out with very high CO2/H2 selectivity to avoid CO poisoning of the fuel-cell anode.
Great efforts have been made to identify ligands with improved α-2 receptor subtype selectivity, to avoid side effects, but thus far this has not been particularly successful.
Although this value is attractive, challenges remain in the field of catalyst development, for example, the minimization (or even elimination) of the noble metal content, maximization of reaction rates at low temperatures, and the optimization of selectivity to avoid undesired side reactions.
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Furthermore, this should help us to discover putative pathogens enhancing auto-immunity after their infection or demonstrating that some selectivity exists to avoid the auto-immune response.
Consequently, we can say that, due to the probable existing selectivity mechanism to avoid auto-immunity already mentioned, the finding of pathogen-exposed proteins that have a stretch of shared sequence, considered as a putative linear B-cell epitope, with human proteins is very difficult.
We propose herein a solution to the FLT3/KIT selectivity problem designed to avoid myelosuppression and also retain potency against drug-resistant mutations.
Besides, to attempt to demonstrate our previous proposal that some selectivity exists to try to avoid the auto-immune response, we obtained a complete set of linear B-cell epitopes from the three most complete and current epitope databases.
We found that well-known protective antigens do not present putative common linear B-cell epitopes with the host proteins, so this fact reinforces what we have postulated before that some selectivity may exist to try to avoid auto-immunity.
They are fabricated by a novel concept to avoid the etching selectivity and residual stress problems during wafer etching.
Swedish population registers contain information on the childbearing of all people ever registered as living in Sweden, and thus allow us to avoid problems of selectivity by the virtue of survival or nonemigration when estimating the fertility measures for previous calendar periods.
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