However, bisphenol AF emerged as a ligand selective for ER-α with a selectivity ratio of 0.15 (Table 3).
These compounds were selective against 11β-hydroxysteroid dehydrogenase type 2 (selectivity ratio >200) and exhibited good inhibition of 11β-HSD1 (IC50 < 1 μM) in a cellular model (3T3L1 adipocytes).
The hydroxy adamantyl amide lead compound was selective against 11β-hydroxysteroid dehydrogenase type 2 (selectivity ratio >1000) and displayed good inhibition of 11β-HSD1 (IC50.1 0.1 μM) in a cellular model (3T3L1 adipocytes).
For each PSSM, we computed selectivity ratios using a range of score thresholds and selected the threshold that produced the largest selectivity ratio.
The threshold value in SR-PLS-DA was selected using the discriminating variables test, DIVA test, and the selectivity ratio plot.
Importantly, across all scans, the chances of a selective infusion, as defined as a fetal left-versus-right FDG selectivity ratio >1.6, were far greater with surgical approach "B" (10 of 11) than "A" (2 of 6).
Compound 170 was the most selective with a potency of 0.61 μM against T. brucei rhodesiense and a selectivity ratio of 23 against MOLT-4.
Thus, the same 1 percent platinum-on-carbon catalyst showed a selectivity ratio of isomerization to hydrogenolysis of 2.5 when the catalyst was reduced in hydrogen at 500 °C (900 °F) and a selectivity ratio of 13 when the catalyst was fired in vacuo at 900 °C (1,600 °F), the percentage dispersion remaining at 35 percent in both cases.
Compound 8a exhibits a selectivity ratio (ER+/ER− cell lines) of >3.5.
The selectivity ratio for H2/N2 was found to be about 7 at 200 °C.
A large proportion of the compounds present a COX-2/COX-1 selectivity ratio between 2 and 4 pIC50 units.
