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The in silico prediction of drug synergisms can represent an important tool for the repurposing of drugs in a realistic perspective which considers also the selectivity of the therapy.
In the field of drug discovery, assessing the potential of multidrug therapies is a difficult task because of the combinatorial complexity (both theoretical and experimental) and because of the requirements on the selectivity of the therapy.
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Some aspects of the dose-proportionality and selectivity of verteporfin therapy were demonstrated in the CAM chicken embryo model.
To test this idea, we implemented an experimentally tractable system to systematically characterize how cell-type-specific drug interactions affect the selectivity of combination therapies, by profiling combinations of antifungal drugs applied to the yeast species Saccharomyces cerevisiae and Candida albicans.
The exclusive accumulation in EVs enhanced the selectivity of the cytotoxic effect exerted by photodynamic therapy to multidrug-resistant cells, without harming normal cells.
The use of such devices has been shown to improve the efficacy of antitumor chemo- and radio-therapies, increasing the selectivity of the cytocidal effects, and reducing systemic side effects.
So now Texas legislators are attacking the academic selectivity of the graduate schools as well.
Arguing about the partiality and selectivity of the report would have achieved nothing.
Gabriel Schoenfeld, of the Hudson Institute, says, "The selectivity of the prosecutions here is nightmarish.
Structural Basis for Substrate Selectivity of the E3 Ligase COP1.
Graduation rates also increase with the selectivity of the college.
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CEO of Professional Science Editing for Scientists @ prosciediting.com