Sentence examples for selectivity of target from inspiring English sources

In the selective binding model, selectivity of target gene activation and repression takes place at the level of DNA-binding.

Recently, the existing lines of evidence have been incorporated into the selective binding model, in which selectivity of target gene activation and repression takes place directly at the level of DNA-binding, and the selective context model.

In addition, ABPs remain bound to the target protease, leading to prolonged retention at the site of interest (i.e. the tumor) and allowing subsequent assessment of selectivity of target labeling using biochemical methods.

Thus, in the here studied cellular system a selective context model is the most likely model to explain how p53 directs cellular outcome, since additional factors like the here shown p53-phosphorylation as well as most likely other PTMs, co-factors and chromatin remodeling influence the selectivity of target gene transactivation and therefore the cellular response pathways.

Taken together, our results highlight the importance of dimerization between MYB and bHLH factors for the selectivity of target genes.

This mode of interaction provides a basis for high affinity and selectivity of target gene recognition and allows for the differential action of TGF-β in different cell types [ 11].

Bispecific antibodies and antibody fragments are a new class of therapeutics increasingly utilized in the clinic for T cell recruitment (catumaxomab anti-EpCAM/CD3 and blinatumomab anti-CD19/CD3), increase in the selectivity of targeting, or simultaneous modulation of multiple cellular pathways.

However, several authors reported that in the adult visual cortex of monkeys and cats it is possible to modify preferred stimuli such as orientation and direction selectivity of targets that optimally excite neurons by a non-preferred adapting stimulus [11], [12].

Further studies also need to obtain the information for SWT components on the specificity and selectivity of targeting the ERs.

For selectivity of targeting, the discrimination between endothelial cells in chronic inflammatory, angiogenic lesions and the normal quiescent vascular endothelium is critical.

We will also add new data from small molecule studies that use a chemical inhibitor of MELK, to demonstrate the selectivity of targeting MELK in basal versus luminal breast tumors.