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Compound 6, however, showed the most selective trypanocidal activity with a selectivity index of 9.8.
Based on Jacobs' selectivity index (D-values), fish larvae always selected for the bigger particles.
selectivity index.
SI (Selectivity Index) = IC50 on mammalian cells/IC50 on parasite.
b: Selectivity index (SI) value equaled to CC50/MIC.
Compound 7a also exhibited the favorable selectivity index (SI = 80).
From these results, the selectivity index was calculated.
The selectivity index of compound 1k was found to be 29.00 in comparison to indomethacin showing selectivity index of 0.476.
The selectivity index (SI) which represents IC50 for normal cell line/IC50 for cancerous cell line.
The cytotoxicity (CC50), effective concentration (EC50) and the selectivity index (SI) values were determined.
Compounds 4o,r and 6d,f had moderate to high selectivity index (S.I).
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