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To each target the ChEMBL database associates a confidence score (see the Compound Selectivity example).
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Since U.S. News measures selectivity, for example, some colleges have blanketed the homes of high school sophomores and juniors with pleas to apply, knowing full well that many of those applicants will be rejected but that the college's ranking may well rise as a result.
The capability to map molecules at the nanoscale will in future provide powerful new insights into molecular adsorption and reaction dynamics at surfaces, ultimately enabling manipulation of process selectivity, for example in catalytic reactions.
The same parameter is used to assess method selectivity (for example, the requirement for diagnostic methods [21] is sensitivity to detect 1% mutant cells in an environment containing 99 wild-type cells).
Further, excellent shape and size selectivity design examples are also introduced.
The outcome is different when fishing is conducted with a gear type that has a sigmoid size-selectivity, for example trawls (Fig. 4D F).
The methodological approach of these later papers is to first select neurons based on their motor properties (for example, selectivity for grasping) and then investigate the responses of this neuronal population to observed actions.
In the case of the KcsA channel, the crystal structure revealed that ions are located in four potential binding sites in the selectivity filter (for example PDB code: 1k4d) [25].
Binding of phospholipids to the annular sites on KcsA shows limited selectivity with, for example, a binding constant for phosphatidic acid relative to DOPC of ∼2.0.
This indicates that these and similar functional groups could be used to further increase the selectivity towards, for example, cancer related CA XII.
This could suggest that these tubules are different in nature to the ALR tubules or that inhibition of the mTOR-activated VPS34 impairs the selectivity mechanism, for example by simply allowing the tubules to persist attached to the originating lysosome.
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