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Compounds in this group exhibited single digit nano-molar potency and some selectivity between the two enzymes.
All tertiary amine derivatives resulted more than 1000-fold less potent than 1 and, unlike prototype, did not show any selectivity between the two enzymes.
Hydrophobic residues for b ions were the primary differences in cleavage selectivity between the two modes, while residues for y ions showed a similar cleavage preference.
The theoretical results allowed explaining the differences in selectivity between the two zeolite structures and the effect of surface dealumination in ITQ-2.
Structure activity relationships and molecular modeling were utilized to gain insight into the structural and chemical features that enhance the binding affinity and selectivity between the two enzyme isoforms.
Further, changes in reaction selectivity between the two reaction environments influenced not only the process product slate but also forced process design features to suppress an unwanted (heavy) by-product.
Similar(41)
This finding might be explained by the temporal (TH-Cre activity precedes that of DAT-Cre) or the spatial (selectivity) difference between the two Cre mouse lines (or both).
The separation of CO2 from CH4 in the natural gas sweetening process would benefit from a membrane material which has a high solubility selectivity between these two molecules.
The difference in selectivity between these three responses was highly significant (p < 10−13).
Interestingly, the chromatographic data demonstrated distinct selectivity trends between the four Fab variant libraries.
In particular, under thermodynamic control, no selectivity is observed between the two competitive routes, either epoxidation or double bond oxidative cleavage, in both the substrates.
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