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However, recent studies revealed that the immuno- suppressive Treg cells only selectively suppress the perforin pathway without inhibiting CTL activation and proliferation in vivo[ 48, 49], suggesting that Treg cells may not suppress the Fas/FasL effector mechanism of CTL in vivo.
Targeted manipulation of this Th17-subtype selective NR2F6 function may represent a unique therapeutic option to selectively suppress and/or reprogram pathological Th17 cell in i.e. multiple sclerosis patients.
This finding suggests that IS3 blockade could selectively suppress the CML-HPCs fraction (i.e., the CD34+ fraction in CML patients).
"We still need to learn how to selectively suppress that part of the immune system that kills insulin-secreting cells," Dr. De Camilli said.
The model demonstrates how the dendritic Ih in pyramidal neurons could selectively suppress AP generation for a volley of excitatory afferents when they are asynchronously and distally activated.
In this study, a series of small-molecular (MW < 500) benzensulfanilamide derivatives were designed to selectively suppress STAT3 activation for anti-cancer treatment.
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Berkeley is making tough choices to balance safety and freedom, not selectively suppressing speech.
Moreover, SPRY4 regulates various signals negatively in angiogenesis, selectively suppressing angiogenic signals independent of Ras in the tumor microenvironment.
BIX-01294, as a diazepin-quinazolin-amine derivative, selectively suppressed the enzymatic activity of histone lysine methyltransferase (HKMT) G9α by binding to its SET catalytic domain.
A phenomenon whereby maternal and paternal chromosomes (or genes) are differentially marked and either maternal or paternal genes are selectively suppressed.
We identify a network that combines fast and slow positive feedback loops as a unique regulatory motif that selectively suppresses differentiation for circadian pulse patterns.
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