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Recent advances in these areas have identified several novel target candidates that represent important avenues for future therapeutic approaches aimed at selectively eradicating the LSC population while sparing normal hematopoietic progenitors in patients suffering from chronic myeloid leukemia.
In summary, fluoroquinolone exposure would have the dual effect of promoting S. aureus colonization while selectively eradicating MSSA strains; the net effect of which is to favor MRSA colonization.
If results from this study warrant in the in vivo investigations in the future, we anticipate that oxidative stress inducers, such as PL, can be an effective means of selectively eradicating cancer cells, which sustain high levels of ROS and are more dependent on anti-oxidant for the survival and susceptible to oxidative stress inducers.
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This approach is expected to generate an effective T-cell (CD8+) response that selectively eradicates tumor cells expressing the EMT driver of choice and undergoing EMT switch.
Therefore, harnessing this mechanism in tumors provides a safe and novel way to selectively eradicate tumor with reduced systemic toxicity and side effects on healthy tissues.
Thus, revealing the differential expression profiles of survival-related genes between normal hematopoietic stem cells and leukemia stem cells will be critical for designing therapies that selectively eradicate CML stem cells while sparing normal stem cells.
We also discuss relevance of these pathways to cancer in light of genetic alterations found in human cancers and review molecular pathways and potential pharmacological strategies to revert or selectively eradicate disorganized tumor epithelium.
It was shown that, like PTL, Celastrol selectively eradicated leukemic stem cells through inhibition of NF-κB survival pathway [35].
Thus, it might become necessary to decontaminate heavily infested caves and other natural sites using safe and effective chemicals that selectively eradicate Gd.
So it will be important to selectively eradicate H. pylori in people that are at the highest risk of developing gastric carcinoma.
Boswellia sp. essential oil may selectively eradicate cancer cells via suppressing intracellular accumulation reactive oxygen radicals as reported in other models [ 70, 71].
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