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The lack of a method for selectively eliminating basophils, leaving mast cells intact, had slowed studies of their functions.
Using mitochondria targeted restriction endonucleases, the authors first tested their system by selectively eliminating the mtDNA haplotype in mouse oocytes and one-cell embryos.
For instance, metronomic chemotherapy could promote tumor eradication not only by inhibiting tumor angiogenesis but also by selectively eliminating immunosuppressive cells and improving anti-tumor immune responses.
Therefore, the clinical potential of the reprogrammed cells could be increased with the development of small molecules capable of selectively eliminating human pluripotent cells like PluriSIn#1[89] and/or programmable SAHA-PIPs.
HER2-expressing EVs have been shown to interfere with therapy and are associated with cancer progression [75]; therefore, selectively eliminating HER-2-expressing EVs could be a new strategy to treat breast cancer.
The most recent report by Reddy et al., for the first time, has prevented the germ-line transmission of mitochondrial disease by selectively eliminating the mutant mtDNA in situ in oocytes and one-cell embryos (Reddy et al., 2015).
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Mei4-GFP is produced only in meiosis because the mei4+ transcript has the determinant of selective removal (DSR) sequence and is selectively eliminated under vegetative growth conditions (Harigaya et al. 2006).
The cells represent a convenient system to screen mutants with alterations in NF-κB pathway: the cells with active NF-κB could be selected in the presence of Zeocin, or could be selectively eliminated in the presence of ganciclovir.
They plan to activate a gene in the mouse that will selectively eliminate senescent cells.
He overcharged on the indictment to build leverage against the defendant and then selectively eliminated charges to win a guilty plea.
Questions from the TV people that have been submitted in advance to Kelly's people are being scribbled over and selectively eliminated.
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