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The present study clearly shows that we were able to generate a phenotype in DC by selectively deletion or reinsertion of specific genes from the viral backbone.
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In addition, the selective deletion of protein phosphatase PP2B selectively abolished postsynaptic PF-PC LTP [22].
Extended Data Fig. 9 RAP2 deletion selectively promotes MCF7 malignancy at low stiffness in vivo.
To overcome this problem, we have designed three group-specific primer sets to selectively amplify the deletion alleles from the nondeletion alleles.
To understand the role of Smad4 loss in head and neck carcinogenesis, we selectively induced Smad4 deletion in oral epithelia.
These results suggest that SALM3 deletion selectively and markedly decreases excitatory synapse number in CA1 pyramidal neurons.
In contrast, p85β deletion selectively reduced centrally localized cell adhesions without disturbing peripheral contacts and adhesion plaques that were enlarged in these cells (Fig. 3A,B); this indicates that p85β is needed for development of peripheral into central cell adhesions.
Additionally, we aimed to examine the effect of RIM1 deletion selectively in area CA3 pyramidal neurons, where it mediates multiple forms of presynaptic plasticity (Calakos et al. 2004; Schoch et al. 2002).
The purified antibody selectively bound the glioma deletion mutant as compared to the intact epidermal growth factor receptor as assessed by immunocytochemistry, immunofluorescence, immunoprecipitation with gel electrophoresis, and binding experiments using radioiodinated antibody.
Recent study of the genome size change in the genus Arabidopsis demonstrates that long (>5 bp) deletions are selectively favored in A. thaliana[ 18].
Furthermore, if DNA insertions and deletions were selectively neutral and unbiased in these regions, then length changes per unit time via indels should be proportional to the region length (as each nucleotide would have the same chance of being an insertion or deletion point).
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