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As an example of this selectivity, transfecting human α-synuclein into the substantia nigra of rats selectively damages the nigrostriatal DA system, despite high levels of transgene expression in non-DA neurons [42].
Increasing evidence suggests that the neurotransmitter dopamine may have a neurotoxic metabolic product (DOPAL) that selectively damages dopaminergic cells.
As a result, if a particular neurotoxicant selectively damages certain neural systems but not others, it can impair some cognitive, sensory, or affective functions, but leave many others intact.
HSV1, which causes the rare and very severe herpes encephalitis, could possibly also produce a milder and chronic brain disease which selectively damages the very same brain areas that are affected in AD [6].
Streptozotocin selectively damages pancreatic insulin-secreting β-cells leading to diabetes [ 19].
Exposure of fish larvae to sublethal concentrations of copper sulfate selectively damages the sensory hair cell population inducing infiltration of leukocytes to neuromasts within 20 minutes.
Similar(51)
For instance, he says, studies of brain-damaged patients have shown that recognition of animals can be selectively damaged.
Auger electrons selectively damage cells in which the isotope decays.
These commonly prescribed antibiotics selectively damage inner ear hair cells leading to hearing loss.
Other agents, such as diphenylhydantoin and ethyl alcohol, selectively damage the cerebellum.
Ultrasound treatments are able to selectively damage targeted tissue - this technology shows an excellent potential for non-invasive localized tumor treatment of benign or cancerous tumors.
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