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If nucleosome N-2 does not interfere with Pho4 binding at UASp2, mutation of UASp1 should selectively abolish cleavage at UASp1, but not UASp2.
10.7554/eLife.03720.007 Figure 3. Nrp1 VEGF- mice selectively abolish VEGF-NRP1 binding in vivo.
The T294M mutation is the first mutation to be shown to selectively abolish the ability of MgADP to stimulate channel activity in the presence of MgATP.
The ability to selectively abolish expression of a single gene and to examine the resulting cellular phenotype has enabled substantial progress in the understanding of gene function.
In contrast the 11β-HSD2 dependent conversion of cortisol to cortisone was efficiently inhibited by both compounds with IC50 (median inhibitory concentration) values in the low micromolar range, indicating that organotins selectively abolish the 11β-HSD2 dependent inactivation of glucocorticoids.
The individual pseudoknot mutations, 'Loop > α' and 'Dock > α', both disrupt the tertiary RNA interaction, and selectively abolish editing at site 1, while preserving editing at sites 2 and 3.
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In addition, the selective deletion of protein phosphatase PP2B selectively abolished postsynaptic PF-PC LTP [22].
The observation, that ERK activation was selectively abolished only in the presence of Lethal Toxin indicates selectivity of the toxins.
This polymorphism selectively abolishes the expression of ACKR1 in erythroid cells, causing a Duffy-negative phenotype.
Notably, our model failed to reproduce electrophysiological data collected from PC-ΔPP2B mice, in which LTP and intrinsic plasticity are selectively abolished in PCs.
These findings indicate that immunolesioning of NK1-R expressing NTS neurons selectively abolishes the depressive effect of somatosensory input on arterial baroreceptor heart rate reflex function.
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