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The selective occupancy of TRIM33 within the active enhancer landscape may account for the minimal phenotypes observed in TRIM33-deficient mice.
Many of the motifs in footprints display highly cell type selective occupancy patterns that are similar to major developmental and tissue-specific regulators [12].
By comparing wild-type AR binding in the absence and presence of its ligand agonist metribolone, we found that AR bound to regulatory DNA elements even when androgen levels were low via selective occupancy of the strongest binding sites, offering molecular evidence for active AR signaling in CRPC tumors [ 2].
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This is partly the result of putting more emphasis on the internet channels and selective rate and occupancy strategies in the different London hotels to best match the opportunities available.
The focal and gene-selective nature of SUMO occupancy resembles the peaks associated with transcription factors, which suggests that there is SUMO modification of TFs.
However, the evidence of selective pressures on 3Hyp site occupancy implies a functional role for the modification itself rather than being simply a coincidental mark of the hydroxylase complex acting as a chaperone during assembly and transport of collagen in the ER.
The growth inhibition at the selective low doses of EPA required occupancy of the epidermal growth factor receptor (EGFR) and was associated with a sustained activation of ERK1/2, which did not occur in non-neoplastic keratinocytes at the same dose.
Occupancy of central H3Rs by ciproxifan, a selective antagonist/inverse agonist, was quantified by [11C]TASP0410457-PET scans of an anesthetized monkey with arterial blood sampling.
Netupitant is a highly selective NK1 RA with a high degree of receptor occupancy.
The tradeoffs that accompany shifts in niche occupancy will typically be accompanied by divergent selective regimes and alternative adaptations.
These two types of CpGs could be defined by specific selective interactions with DNA binding proteins or by fixed nucleosome occupancy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com