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At both ancient and recent stages of symbiosis evolution, gene loss was at least partially influenced by selection, highly conserved genes being retained more readily than lowly conserved genes: although losses might result from drift due to the bottlenecking of endosymbiontic populations, we demonstrated that purifying selection also acted by retaining genes of greater selective importance.
We argue that facultative placentotrophy should have selective importance relevant to offspring fitness.
Nature 457, 318 321 (2009).This is a demonstration of the restriction of Spi-C expression to red pulp macrophages and its selective importance for their red pulp macrophage development and hence for splenic iron homeostasis.
The selective importance of heme in tumor cell proliferation and function is also consistent with the previous observation that NSCLC cells require serum (containing heme) for maintenance and proliferation, whereas the normal lung cells survive and proliferate better with growth factors in the absence of serum [148, 149].
Apart from initially neutral processes like gene duplication, several other mechanisms of selective importance could generate clustering of genes.
On the one hand, a variety of dietary components may have lost their selective importance during the agricultural transition due to a better controlled food consumption.
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We propose a new object tracking algorithm by local structural manifold learning in a selective sampling importance resampling (SSIR) particle filter framework.
Despite its importance, selective contracting is uncommon in the Netherlands [ 35].
To evaluate the selective or functional importance of genes, we used a parameter that measures the level of adaptive codon bias in E. coli (i.e. codon adaptive index, or CAI), and also estimates of evolutionary rates (Ka) between pairs of orthologs either in free-living bacteria or in pairs of symbionts.
To evaluate the selective or functional importance of genes, we used a parameter that measures the level of adaptive codon bias in E. coli (i.e. codon adaptive index, or CAI), and also estimates of evolutionary rates (Ka) between either pairs of orthologs in free-living bacteria or in pairs of symbionts.
Analyses similar to our present study in a bigger cohort of infected animals followed prospectively would be important to further substantiate the importance of selective deficiency in one or more cytokine producing memory subset of CD4 T cells as a preferred predictive marker of disease progression.
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