While trypanothione reductase has structural similarity with its human homologue glutathione reductase, which could potentially impede the path to design selective analogues, the other two enzymes TS and TP hold the promise of delivering selective inhibitors against them.
Radioembolization (RE) implements intra-arterial administration of microspheres coated with yttrium-90 (90Y), a ß-emitting isotope, delivering selective internal radiation to the tumor.
(i) What is the biological role of the bulk of ingested sialyllactose that is not digested and (ii) what is the selective advantage of delivering Sia to the suckling pup instead of ManNAc or GlcNAc?
The selective approach involves delivering programs which target specific populations, such as individuals at greatest risk for developing substance use problems.
Since the CFs contain certain Abs, but not all, there is a selective process for delivering Abs to this site, and it is important to test Abs to a wide range of other antigens.
Spin techniques may include careful timing in delivering information, selective presentation of facts, careful selection of words and phrases meant to invoke certain responses in hearers, choice of sound bites, or redefining of terms and phrases.
Since this approach led to probes that were also recognized by caspases, we introduced a Counter Selection Substrate Library (CoSeSuL) approach that biases the peptidic scaffold against caspases, thus delivering highly selective legumain probes.
2, 24 By delivering nociceptive selective stimuli to the same sites, we also detected, for the first time, a clear gradient of spatial acuity for pain.
Dually modifying the interior of a VLP with a functional material, while simultaneously displaying targeting ligands on the exterior surface, can produce highly selective nanoparticles, capable of delivering a payload to specific cells or tissues.
Editor's note: Guest contributor John Katzman is the founder and CEO of 2tor, an education startup that partners with universities to deliver selective degree programs online to students across the world.
