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Social niche The selective context in which social behaviour occurs, affecting the strength and direction of selection on it.
Discursive in organization, "A Pretext for War" provides selective context for the failure to prevent the attacks of 9/11 and the Bush administration's path to war.
In the selective context model, p53 is thought to first bind to all accessible sites in the genome after which other determinants like p53-binding factors and the presence of p53 PTMs determine the cellular outcome.
Recently, the existing lines of evidence have been incorporated into the selective binding model, in which selectivity of target gene activation and repression takes place directly at the level of DNA-binding, and the selective context model.
In the selective context model p53 first binds to all accessible sites in the genome and then other determinants like post-translational modifications of p53, the presence of co-factors and chromatin architecture determine cellular outcome [4].
Thus, in the here studied cellular system a selective context model is the most likely model to explain how p53 directs cellular outcome, since additional factors like the here shown p53-phosphorylation as well as most likely other PTMs, co-factors and chromatin remodeling influence the selectivity of target gene transactivation and therefore the cellular response pathways.
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According to Slote, when we say that such and such is unavoidable for a person, we have in mind "selective" contexts in which the facts pertaining to the unavoidability have nothing to do with that person — the facts bypass that person's agency altogether (Slote, 1982, p.19).
Some studies have shown selective context-related signals in the hippocampus [ 1, 14]; others have shown both item and context signals [ 2, 15].
Combined with spatial information from the medial entorhinal cortex it is hypothesised that this contextual information is used to form an integrated spatially selective, context-specific response in the hippocampus that underlies episodic memory.
This could occur via a priori predictions of mutational routes for specific populations in given selective contexts.
In the well-established model species Fundulus heteroclitus, the species has evolved both highly plastic and locally adapted phenotypes within different selective contexts [ 11].
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