Sentence examples for selective compound from inspiring English sources

The most selective compound, 2k, presents a selectivity index value of 6200 and an IC50 of 10 nM against the parasite.

To ensure that the sensitivity to β5 inhibition was not compound specific, we performed the same treatment using WL588, another β5 selective compound that we identified with a smaller window of selectivity for β5 than PR709A (Supporting Information Figure 4).

The most active compound (3a) has the IC50 of 0.50 μM for AKR1B10, and the most AKR1B10 selective compound (2a) has the IC50 of 0.81 μM with AKR1B1/AKR1B10 selectivity of 195.

These differences were not explained by the HDAC selectivity of these inhibitors alone since apicidin, which is a class 1 selective compound similar to depsipeptide, also showed a unique drug sensitivity profile of its own.

We selected PD173074 for in vivo assessment as it was the most potent and selective compound, with the lowest IC50 values and the most pronounced cell cycle and apoptotic effects in vitro.

Extensive SAR studies supported by molecular modeling afforded a highly potent and selective compound 36.

However, the β5c-selective inhibitor compound 14, which was the most isoform-selective compound in vitro, displayed substantial selectivity for the constitutive proteasome in cells.

The loss of substrate-selectivity in the dual substrate assay was also replicated with a proprietary substrate-selective compound (data not shown).

Carbamate 9 and tosylate 13 displayed subnanomolar affinity for the MOR, while 10 was the most μ-selective compound synthesized.

Membranes of dicyclohexano-24-crown-8 (I) as an ion-selective compound in poly vinyl chloride) (PVC) based matrix have been tried for cadmium II -selective sensors.

The specific binding was determined by comparing a vehicle group with a blocking group pre-treated with a high dose of a target-selective compound or a wild-type (WT) group with a target knock-out (KO) group mimicking complete target occupancy.