VCP modulates the ubiquitin-dependent proteolysis of selective clients by proteasome, ER-associated degradation and/or autophagosomes; this underscores the link between SGs and proteostasis.
It's not clear how selective these clients are at this point, but they're going to have have to start making choices, otherwise users are going to be overwhelmed with the number of services they have at their disposal.
(35 year old female, Bulawayo) This strategy, of course, only worked some of the time, and many could not afford financially to be selective with clients.
CMA is a form of selective autophagy whereby client proteins are targeted to lysosomes for degradation without the requirement for autophagosome formation.
Stress-independent HSF1 activation selectively induces the expression of promiscuous cytosolic HSP40s (e.g., DNAJB1 and DNAJA1) but not HSP40s that demonstrate selective or no client binding (e.g., DNAJC10 and DNAJC11).
HSP40s can be classified into four categories defined by their binding to substrates: (1) promiscuous client binding, (2) selective client binding, (3) no client binding, and (4) unknown client binding.
Most high-end providers are extremely selective about their clients.
Both say they are selective in choosing clients and have no intention of building a monopoly.
Today, the business, started in 1988, generates enough revenue for the Dukes to be selective in acquiring clients.
We are selective in the clients who we take on and, likewise, you should be careful in choosing an attorney.
Mr. Higginbotham said that some banks had become more selective about their clients, trying to aim lending at those who might buy several types of financial services.
