Thus, how JNK executed cell elimination remained elusive.
While scrib cell elimination depends critically on JNK signaling, JNK-dependent cell death cannot sufficiently explain scrib cell extirpation.
c, Distribution of time constants for trial-time or session-time selective cells (n = 80 cells).
Takeichi, M. Cadherins: a molecular family important in selective cell-cell adhesion.
Of note, a previous report demonstrated that β-cell-selective elimination of PPARγ resulted in significant islet hyperplasia (29).
Given that IFN-γ contributes to T-cell homeostasis in vivo through inhibition of proliferation and/or by increasing AICD 23– 28, 28, a simple additional explanation for the increased proportion of Foxp3+ cells might be selective elimination of Foxp3– cells and, indeed, preliminary results showed a clear correlation between proliferation and AICD in this system (not shown).
If so, then doxorubicin would preferentially lower the apoptotic threshold in cancer cells and facilitate the selective elimination of these cells.
On the other hand, it has a negligible cytotoxic effect on differentiated cells, thereby enabling selective elimination of human iPSCs in a mixed cell population (Tateno et al. 2015).
Importantly, inhibition of the mitochondrial respiratory chain appears to prevent the accumulation of these slowly proliferating CDDP-insensitive cells, delineating a strategy for the selective elimination of malignant cell clones that initially resist CDDP-based chemotherapy.
In addition, this study demonstrates that the potential now exists, in principle, for the controlled selective nuclear elimination of any eukaryotic cell.
Here we have shown, using complementary in vitro and in vivo functional assays, that inhibition of c-FLIP (FLIPi) overcomes resistance of breast cancer stem cells (bCSCs) to the anti-cancer agent TRAIL, resulting in the selective elimination of stem cell characteristics in all of the cell lines tested, independent of hormone receptor status.
