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Deltombe T, De Wispelaere J-F, Gustin T, Jamart J, Hanson P. Selective blocks of the motor nerve branches to the soleus and tibialis posterior muscles in the management of the spastic equinovarus foot.
This approach was chosen because (i) selective blocks are important for cardiac drug discovery and (ii) it allows a controlled and systematic comparison between different cell types or models, which is a preliminary step before extending the analysis to more complex drug effects including multichannel actions.
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The apparent selective block in T cell positive selection and early B cell development in Lmna-/ mice hinted at specific developmental checkpoints at which A-type lamin function was required.
The novel pyrazole Pyr10 displayed substantial selectivity for TRPC3-mediated responses (18-fold) and the selective block of TRPC3 channels by Pyr10 barely affected mast cell activation.
These results suggest that selective blocking of pro-angiogenic isoforms by inhibiting splice-site selection with SRPK1 inhibitors reduces melanoma growth.
Selective blocking of Ca2+ stretch-activated channels.
Finally, we demonstrated whether selective blocking of the miR-223 NLRP3 IL-1β miR-223 NLRP3 IL-1β-inducouldLI.
Beeton, C. et al. Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation.
Pinheiro, P.S. et al. Selective block of postsynaptic kainate receptors reveals their function at hippocampal mossy fiber synapses.
The hydroxyl groups produced upon water adsorption were used for selective blocking of the active sites.
Compared with other channels, GFA showed selective blocking activity in late sodium channel.
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