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We also introduced the concept of strain index and showed how it can be used to identify portals that have the potential of being highly selective between two molecules.
Although peptides based on overall hydrophobic interactions are less selective between bacterial and eukaryotic lipid membranes, which risks resulting in an enhanced cytotoxicity of more hydrophobic AMPs [21], carefully balancing hydrophobicity and charge in a sequence-specific way may result in short, potent antimicrobial peptides displaying low mammalian cell toxicity (e.g., [43]).
The sizes of the excluded volumes were tuned manually until the pharmacophore model was sufficiently selective between actives and inactives.
More importantly, INZ is more selective between cancer cells and normal cells compared to Tenovin-6 (Fig S8C of Supporting Information).
In smooth muscle from portal vein, for example, caffeine, ryanodine, Ca2+, or extracellular stimuli that evoke an increase in cytosolic Ca2+ concentration stimulated opening of high-conductance (γK ∼ 190 pS) cation channels that were permeable to Ca2+ and Ba2+, and only modestly selective between cations (PCa/ PNa ∼ 21) [although more so than conventional RyR (184)] (163).
Similar(53)
SB-273779 has irreversible binding characteristics the CGRP receptor [15] and is non-selective between CGRP and AMY1 receptors (data not shown).
Cytotoxic drugs are non-selective between normal and pathological tissue, and this poses a challenge regarding the strategy for treatment of tumors.
Differences in selective pressures between species, and between mothers and offspring, are likely to drive the timing of the onset of mother-young recognition.
Additionally combinations between non-selective and selective contacts between receptors and ligands are possible (figure 3c ii).
Selection analyses revealed that all homeologs evolved under purifying selection and did not detect differential selective regimes between them (Table 1).
However, we only found weak evidence for varying synonymous substitution rates between loops and helices, implying that selective differences between these regions are not strong.
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