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Given the complexity of gene environment interaction analyses, there may be problems with selective analyses and selective reporting of results in a fragmented and possibly biased fashion (Ioannidis 2005).
Statistical methods to analyze HTE in humans, in particular "subset" or "subgroup" analysis, must therefore navigate treacherous waters, taking pains to avoid, for example, data dredging through selective analyses that fail to account for multiplicity (Byar 1985; Kravitz et al. 2004; Rothwell 2005; Willke et al. 2012).
Based on our strong a priori hypotheses, we followed a large body of previous P300 research by focusing the main analyses on the mid-parietal electrode site (Pz in 10/20 nomenclature), where P300 effects are consistently largest and where selective analyses are typically focused in GKT research.
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To date, some research involving selective sweep analyses in pigs has revealed strong signatures of selection affecting genomic regions that harbor genes underlying economic traits such as body length, disease resistance, pork yield, muscle development and fertility (Amaral et al. 2011; Li et al. 2014).
CCM, MTAD and NBL carried out selective pressure analyses.
This guarantees use of the most flexible solution for selective comparative analyses between groups of organisms.
CCM, KS, AEW, and TAW carried out all selective pressure analyses and designed the necessary software.
Selective pressure analyses were performed using Codeml from PAML version 4.4 [ 36, 37].
Finally, our selective constraints analyses show evidence of adaptive evolution in mAng6.
CCM, NBL and MJO'C carried out all selective pressure analyses.
For further selective sweep analyses, we collected blood from 11 F0 animals from FL and LL and from nine F1 (FL × LL) animals for genome resequencing.
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