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Hence, climatic gradients in tropical Africa are probably the first major driver of differentiation in the genus Erythrophleum, but additional tests based on molecular signatures of climate-driven selection would be necessary to confirm this hypothesis.
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Grattapaglia and Resende (2011) suggested that for forest trees a density of 10−20 markers per centimorgan would be necessary for genomic selection, depending on the degree of LD in the training and selection populations.
We have already noted that if the optimal solution to the sample selection problem was to be guaranteed it would be necessary to evaluate the fitness of every possible sample subset of the desired size, which is in general unfeasible in practice.
Compromise or relative weighting would be necessary to select valuable sites for conservation because of inherent contradictions among some reserve selection criteria.
The panel will not be sequestered during jury selection either, although defence lawyers argued such a measure would be necessary since the case has a high public profile.
We also discuss that more field trials over successive years as well as more extensive accession sampling would be necessary to fully validate a fluctuating selection model.
Further investigations with alternative tests on within-species variation [ 10, 12, 14, 15] would be necessary to detect evidence of positive selection and elucidate the differential rate of adaptive substitution among the GA pathway genes.
In our opinion, a combination of drift and selection on germ line mtDNA population, might be responsible for the maintenance of viable mitochondrial genetic information through generations, and a mitochondrial activity would be necessary for the selective process.
More complete fossil hands from the African Mio-Pliocene transition would be necessary to clarify this issue, especially regarding of the selection pressures underpinning the remarkable human-like features of the Orrorin PDP.
The suggestion is that natural selection would favor genotype with low mutability although an accumulation of germinal mutations would be necessary for preservation of an evolutionary plasticity.
Rather, mutations or chromosome damage would be necessary to induce leukaemia, but a proliferative stimulus (infection) causing a selection of the mutated clones would also intervene.
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