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Library design and reagent selection was guided by the use of a pharmacophore model and synthesis of the array was enabled with a general solid-phase method.
Deficit selection was guided by two imperatives.
Primer selection was guided by uniqueness of the oligonucleotide sequence across the human genome, as well as the CpG distribution within the 1 Kb sequence window.
Model selection was guided by the Akaike information criterion (AIC), which assesses the fit between the data and the model with a penalty for the number of parameters (i.e. favoring the more parsimonious model).
Model selection was guided by the decrease in the objective function value (−2×log likelihood).
This selection was guided by growth variability reported in the literature.
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Positive selection is guided by immediate selective advantage, whereas purifying selection may optimise the function of already existing adaptations (e.g., reduce energy costs, increase reliability and adaptability).
Modality selection were guided by the hospital guideline.
They conclude that requirements for effort-intensive cognitive control are anticipated during the selection of specific actions and thus, that action selection is guided by the anticipation of action outcomes.
Supported by evidence from brain imaging in human subjects, the model proposes that action selection is guided by hierarchically ordered control signals, processed in a network of brain regions organized along the anterior posterior axis of the lateral prefrontal cortex.
If natural selection were guided and orchestrated by the God of theism, for example, the worry would disappear; God would presumably use the whole process to create creatures of the sort he wanted, creatures in his own image, creatures with reliable cognitive faculties.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com