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The system was augmented by application of numerical scores as has been done previously for selection of toxicity data for CPY [38].
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Reasons for this include selection bias and inconsistent reporting of toxicity data.
For each chemical substance indexed in RTECS, six types of toxicity data are included: (1) primary irritation; (2) mutagenic effects; (3) reproductive effects; (4) tumorigenic effects; (5) acute toxicity; and (6) other multiple dose toxicity.
Repeated doses of NB-598 were well tolerated throughout the course of the studies, with no overt signs of toxicity (data not shown).
The maximally tolerated dose of CBDCA was conceptually defined as that dose, determined by logistic regression analyses of toxicity data, resulting in a 50% incidence of moderate toxicity (MOD50) or a 5% incidence of severe toxicity (SEV5).
Collection of toxicity data was through medical chart review and thus not as complete as prospective toxicity data collection.
For the selection of the liver toxicity data to be used for modeling, we considered the compounds for which LOAEL related to effects on liver was reported and we labelled them as "active" substances.
Health information is posted on the agency's IRIS, based on reviews of chronic, toxicity data by EPA scientists.
The number of missing toxicity data was small (0.46%).
Existing toxicity data are then used to recommend specific approaches for characterizing mixture toxicity (addition models, independence models, case-by-case assessments, or use of whole mixture toxicity data).
Table 2 Toxicity data of transition metals.
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