Molecular marker analysis, joined to phenotypic evaluation, is a powerful tool for grouping of genotypes based on genetic distance data and for selection of progenitors that might constitute new breeding populations.
Selection of progenitors was performed first by choosing the 3 earliest plants within each row of Early progenitors (total of 12 plants per progenitor within Early populations) and the 3 latest plants within each row of Late progenitors (total of 12 plants per progenitor within Late populations).
Doxorubicin selection of the progenitor cells had no effect on the viability of the cells during LC culture (Fig. 3a).
Binary differences in retinoid activity result in graded shifts in expression of a pivotal transcription factor, Ascl1, which is critical for the selection of alternate progenitor identities.
The most well-established function for Notch signaling in neural development is the selection of neural progenitor cells through a process termed mutual or lateral inhibition (Artavanis-Tsakonas et al., 1999).
In Drosophila, the regulatory relationships between Notch, Hes and proneural bHLH genes are highly similar; however, Notch signalling in Drosophila acts in the selection of neural progenitor cells from ectodermal cells, rather than in the maintenance of an undifferentiated population of NPCs (Hartenstein and Wodarz, 2013).
Strategies aimed to improve the myelinogenic potential of hNSCs in vivo include direct selection of committed progenitors [3][5][45], genetic [31] or epigenetic manipulation [40] [36] [47], [51], [51] of hNSC towards the lineage of interest.
An alternative explanation for the latter phenotype is defective Myb-mediated selection of Svp progenitors from cardiac mesoderm equivalence groups.
In addition to their role in the selection of neuronal progenitors within the neuroepithelium, vertebrate proneural genes have also been shown to specify neuronal subtype identities.
Transcriptome analyses of neural differentiation have been carried out following selection of neural progenitors in vivo and by analysing differentiating ES cells (Li et al., 1998; Aubert et al., 2003; Abranches et al., 2009; Wu et al., 2010).
