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Selection of interaction terms screened for inclusion in the final models was governed by perceived clinical significance and made a priori to analysis.
Selection of interaction terms screened for inclusion in the final models was governed by clinical significance and terms were added to models one by one rather than stepwise [30].
Other algorithms apply thermodynamics as the initial requirement for selection of interaction sites between miRNAs and their targets.
Selection of interaction effects for the adjusted model followed the model selection process described by Collett using a p value of 0.10.
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Five stages are evaluated: systematic interaction analysis, arrangement of components, identification of interactions, selection of interactions and configuration analysis.
Moreover, the two processes of selection of interactions (clustering vs. expertise) are radically different since the second phase.
Each rater coded a selection of interactions from both assessment phases (pre, 1-year-follow-up).
We introduce a package for the R statistical language to implement the Multifactor Dimensionality Reduction (MDR) method for nonparametric variable selection of interactions.
17 A stringent criterion for the selection of interactions as combined edge score greater than 0.9 (P-values for Bayesian confidence score) resulted in a basal network, composed of 3056 nodes and 18233 interactions.
Although most significant interactions found by our method on experimental data were limited to two or three genes, there are no theoretical limitations to the size of interactions that can be searched, at no particularly higher computational cost, setting this method apart from other recent work on penalized selection of interactions in high-dimensional data (Bien et al., 2012).
The package 'MDR' implements MDR for variable selection of interactions as first outlined in [ 1] and described in more detail in [ 4], providing options for internal validation and functions to summarize the fit and perform post-hoc inference, and is available at http://www.r-project.org/.org/
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