Sentence examples for selection of insertion from inspiring English sources

Currently, there is no robust guideline for selection of insertion sites ensuring the desired functional outcome of insertional fusion.

Our study indicates that when developing genetically modified crops, a judicious selection of insertion sites, based on knowledge of selective (dis)advantages of the surrounding crop genome under field conditions, could diminish transgene persistence.

The system also employs a removable drug resistance marker that allows for selection of insertion events into expressed genes.

If this is indeed so, this property of RecET recombination is extremely advantageous for the selection of insertions into the bacterial chromosome or large plasmids after the "pop-out" step of the "pop-in, pop-out" scheme of recombinogenic engineering ([ 17], reviewed in [ 18]).

This is in agreement with the results regarding the transcriptional activity of CIS genes (significantly different between HSC in vitro and T cells in vivo from HSC-GT patients, Fig S6 of Supporting Information) and again points to a more complex mechanism of physiological selection of insertions upon in vivo differentiation.

Selection of the insertion site should be based on both the ease and the risks of the procedure.

Selection of the insertion site should be based both on the ease of placement and on the risks associated with the procedure.

To address the problem of finding intron insertions for less efficient introns, we have engineered a vector with a retrotransposition activated kanamycin resistance marker that allows selection of intron insertion events [ 30].

Therefore, this mechanism may be similar to the known depletion of TEs in promoters caused by the negative impact of TE insertions in genomic regulatory regions; TEs are preferentially found outside of promoter regions not because of selection for insertion in intergenic regions but rather owing to negative selection against insertion in promoters.

The vectors developed permit screening for the desired insertion through PCR or direct selection of intron insertions using a selection scheme that activates a kanamycin resistance marker upon successful intron insertion.

Nonreference Genome Germline Insertions Validated by Site-Specific PCR, Related to Figures 2 and 3 Different tabs are included for a set of 200 random insertions and for a selection of 36 insertions in cancer candidate genes.