The phrase "selection of dose" is correct and usable in written English.
The phrase can be used when referring to the act or practice of selecting or choosing a particular dose or dosage of a medication. For example, "The doctor had to carefully consider a selection of dose in order to prescribe the right medication for his patient's symptoms."
To help promote increased consideration of the important role TK can play in chemical risk assessment, we have gathered practical examples from the peer-reviewed literature, as well as in-house industry data, that highlight opportunities for the use of TK in the selection of dose levels.
Applying biomarkers in early clinical trials helps identify the most appropriate patients; provides proof of concept for target modulation; helps test the underlying hypothesis; informs the rational selection of dose and schedule; aids decision making, including key go/no go questions; and may explain or predict clinical outcomes.
Selection of dose was based on previous studies [38, 39].
These studies were used to underwrite the selection of dose for clinical studies.
Selection of dose regimen and treatment duration was based on pharmacokinetic modelling and simulations.
We therefore approached the selection of dose categories de novo, using tertiles and quartiles of dose.
One of the major challenges in the design of double-blind flexible-dosing clinical trials comparing active drugs is the selection of dosing regimens that are equivalent across drugs.
Clinicians involved in the opioid pharmacotherapy of cancer-related pain should be acquainted with a variety of opioids and be skilled in the selection of doses when the type of opioid or route of administration needs changing.
These findings confirm the modeling and empirical results that led to the selection of doses tested against warfarin in ROCKET AF.
Richard Hargreaves, executive director of imaging at Merck Research Laboratories, says, "Nuclear imaging using radiotracers gives the opportunity to put your arms around proof-of-concept very early in a drug discovery and development program by focusing the selection of doses to study on those proven to deliver enough drug to the target therapeutic sites".
It should be noted that our selection of doses of each agent were based on MTD in SCID mice as determined by weight loss greater than 20%.
