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It can be inferred that the proper selection of confidence levels will help achieve a tradeoff between economy and reliability.
Moreover, the results indicated that the performance of the proposed fuzzy models was not significantly sensitive to selection of confidence level in data (h) and improved slightly as h increased.
This analysis provides an indication of how the selection of confidence thresholds affects the accuracy and efficacy of the imputations.
Unlike many alternatives, which are based on a set of heuristic rules and thresholds, the probabilistic interpretation of the final decision allows for decision control by simple selection of confidence levels, which makes the proposed system flexible for clinical needs (Deburchgraeve et al., 2008; Navakatikyan et al., 2006).
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Here, though, his team acted as if this was a first-choice selection, full of confidence and endeavour.
The selection of a confidence level (e.g., 95%) specifies the probability that the confidence interval calculated will include the true parameter value.
Technical variation of the workflow is very low with selection of high confidence peptide spectral matches ensuring that quantification is only calculated from good quality matches, reducing technical variation and ensuring low false discovery rates.
The workflow from in silico SNP discovery in the Sce_Assembly02 to selection of high confidence SNP candidates was a three-step procedure: First, the tool GigaBayes V0.4.1 [ 41] was applied with parameter settings given in Additional file 3. Second, characteristics for discovered SNPs were extracted by in-house implementations to compute defined selection criteria for candidate SNPs.
A few alignment algorithms output site-specific scores that allow the selection of high-confidence regions.
Sanger resequencing of SNPs did find, however, that a second SNP allele was not always identified in the 454 sequencing datasets at the coverage cutoff used for selection of high-confidence SNPs (Additional file 5, Table S2).
For the selection of high-confidence variants for the 600 k array, we applied a voting system based on (i) their performance on the screening arrays, (ii) concordance of array genotyping calls with in silico variant calls from sequencing data of the 30 maize lines in the discovery panel, and (iii) over- or under-representation of the corresponding bin.
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